OPCs
Summary
OPCs are the precursor to oligodendrocytes, and have been shown to support immunity and healthy inflammation, as well as cardiovascular health including lipid per-oxidation, platelet aggregation, nerve health/regeneration and capillary health. Because of the wide range of influence OPCs have in the human body, this class of polyphenols can help support health on many levels. OPCs have also been shown to support bone, brain, eyes and skin.
OPCs are recently discovered and not well quantified, the below sources are confirmed and loosely ordered, but the DV remains unknown.
Oligomeric proanthocyanidins (OPCs) are a class of powerful antioxidants found in a variety of plants, particularly in grape seeds, pine bark, and certain fruits. They are part of the flavonoid family, which is known for its beneficial health effects. Here's a detailed look at OPCs and their health benefits:
Health Benefits of OPCs
Antioxidant Properties:
OPCs are potent antioxidants, which means they help neutralize harmful free radicals in the body. This action helps protect cells from oxidative stress and damage, which is linked to aging and various chronic diseases.
Cardiovascular Health:
OPCs can improve cardiovascular health by enhancing blood circulation, strengthening blood vessel walls, and reducing inflammation. They have been shown to lower blood pressure and cholesterol levels, which are critical factors in preventing heart disease.
Anti-Inflammatory Effects:
The anti-inflammatory properties of OPCs can help reduce chronic inflammation, which is associated with many health conditions, including arthritis, allergies, and autoimmune diseases.
Skin Health:
OPCs support skin health by protecting against UV radiation damage, improving elasticity, and promoting collagen production. This leads to healthier, more youthful-looking skin and can help prevent premature aging and skin disorders.
Improved Immune Function:
By boosting the body's antioxidant defense system, OPCs can enhance immune function, helping the body to fight off infections and diseases more effectively.
Eye Health:
OPCs are beneficial for eye health, particularly in preventing conditions like macular degeneration and cataracts. They improve blood flow to the eyes and protect against oxidative stress.
Cancer Prevention:
There is ongoing research into the role of OPCs in cancer prevention. Their antioxidant and anti-inflammatory properties may help reduce the risk of certain types of cancer by preventing DNA damage and inhibiting tumor growth.
Sources of OPCs
Grape Seed Extract: One of the richest sources of OPCs, often used in supplements for its potent health benefits.
Pine Bark Extract: Known as Pycnogenol, it is another popular source of OPCs with extensive research backing its efficacy.
Berries: Blueberries, cranberries, and strawberries contain significant amounts of OPCs.
Cocoa: Dark chocolate and cocoa products are good sources of OPCs, contributing to their health benefits.
Supplementation and Dosage
OPCs are available as dietary supplements, often in the form of capsules or tablets. The recommended dosage can vary based on the specific product and individual health needs, but typical doses range from 50 to 300 mg per day. It's important to follow the dosage instructions provided by the manufacturer or consult with a healthcare professional for personalized advice.
Safety and Side Effects
OPCs are generally considered safe for most people when taken as directed. However, some individuals may experience mild side effects such as digestive discomfort or allergic reactions. It's advisable for pregnant or breastfeeding women, as well as individuals with specific health conditions or those taking medication, to consult a healthcare provider before starting OPC supplementation.
OPCs are a powerful and versatile group of antioxidants that offer numerous health benefits, from protecting against oxidative stress to supporting cardiovascular health and improving skin vitality. Incorporating OPC-rich foods or supplements into your diet can be a valuable strategy for enhancing overall health and preventing chronic diseases. As always, it's best to approach supplementation with guidance from a healthcare professional to ensure safety and efficacy
Below, you'll discover foods with the highest concentrations of OPCs. Remember to consume them in moderation, as excessive intake of any nutrient can have adverse effects on your health.
High OPCs Foods (from highest to lowest, per 100 grams)
High Fat Diet
Lion’s Mane Mushrooms
Apples
Grapes
Pears
Wild Blueberries
Strawberries
Raspberries
Black Currants
Cranberries
Red Wine
Cashews
Hazelnuts
Pecans
Pistachios
Avocado
Cheese [Grass Fed]
References
Admin. (2021, November 18). OPC - Oligomeric proanthocyanidins. QIDOSHA. https://qidosha.com/en/blogs/product-knowledge/opc-oligomeric-proanthocyanidins#:~:text=OPC%20stands%20for%20Oligomeric%20Proanthocyanidins,and%20protects%20it%20from%20oxidation.
NCI Drug Dictionary. (n.d.). Cancer.gov. https://www.cancer.gov/publications/dictionaries/cancer-drug/def/oligomeric-procyanidin-complex
Oligomeric proanthocyanidins (OPCs). (2024, June 7). OptiHealth Products. https://optihealthproducts.com/blogs/news/oligomeric-proanthocyanidins-opcs
OPCs — Oligomeric proanthocyanidins. (n.d.). Everand. https://www.everand.com/article/573230759/Op-Cs-Oligomeric-Proanthocyanidins
Ravindranathan, P., Pasham, D., & Goel, A. (2018). Oligomeric proanthocyanidins (OPCs) from grape seed extract suppress the activity of ABC transporters in overcoming chemoresistance in colorectal cancer cells. Carcinogenesis, 40(3), 412–421. https://doi.org/10.1093/carcin/bgy184
Williams, H., & Williams, H. (2023, November 8). OPCs: The super antioxidant with promising health benefits | Dietitians On Demand Blog. Dietitians on Demand | Professional Recruiting Services for Contract and Permanent-hire Positions. https://dietitiansondemand.com/opcs-the-super-antioxidant-with-promising-health-benefits/